SEC 13F Intelligence

Managers / Q3 2025 · view latest →

HighVista Strategies LLC

CIK 0001335325 · 200 CLARENDON STREET, 50TH FLOOR, BOSTON, MA, 02116 · 617-406-6500

Reported Value
$408M
Q3 2025
Positions
148
Filings on Record
30
2019–present window
Filed
Nov 14, 2025
original filing

Summary

Highvista Strategies LLC reported $408M in U.S.-listed holdings across 148 positions for Q3 2025.

Its largest position, DBC, represents 7.9% of the portfolio.

Compared with Q2 2025, the fund opened 29 new positions and exited 27.

Portfolio Metrics

Turnover
+17.3%
vs prior filed quarter
Top-10 Concentration
+29.1%
share of reported value
Largest Position
+7.9%
Invesco Db Commdy Indx Trck
New / Exited
29 / 27
positions this quarter

Methodology: turnover is min(value bought, value sold) ÷ average reported value across the two quarters — value-based, so market moves inflate it slightly versus a share-based measure. Concentration and largest position are shares of the filing’s total reported value, options excluded. New/exited counts compare against the prior filed quarter. All figures derive solely from the fund’s 13F filings.

Reported Value by Quarter

13F Reported Value
Q4 ’18: $116MQ4 ’18Q1 ’19: $123MQ2 ’19: $195MQ3 ’19: $147MQ4 ’19: $132MQ4 ’19Q1 ’20: $108MQ2 ’20: $121MQ3 ’20: $137MQ4 ’20: $157MQ4 ’20Q1 ’21: $135MQ2 ’21: $141MQ3 ’21: $151MQ4 ’21: $126MQ4 ’21Q1 ’22: $157MQ2 ’22: $166MQ3 ’22: $175MQ4 ’22: $168MQ4 ’22Q1 ’23: $123MQ2 ’23: $219MQ3 ’23: $216MQ4 ’23: $276MQ4 ’23Q1 ’24: $280MQ2 ’24: $274MQ3 ’24: $290MQ4 ’24: $269MQ4 ’24Q1 ’25: $260MQ2 ’25: $272MQ3 ’25: $408MQ4 ’25: $388MQ4 ’25Q1 ’26: $362Mfilingsflow.com

Portfolio Composition

By security type
Common Stock: 74.4%ADR: 9.5%Other: 8.2%ETP: 7.9%
  • Common Stock · 74.4% · $303M
  • ADR · 9.5% · $39M
  • Other · 8.2% · $33M
  • ETP · 7.9% · $32M

Quarter-over-Quarter Changes full breakdown →

vs Q2 2025 (amended baseline)

IssuerMoveShare ΔShares nowValue ΔValue now
CDTXCIDARA THERAPEUTICS INCNEW+70.9K70.9K+$7M$7M
GOOGALPHABET INCNEW+9.8K9.8K+$2M$2M
CRH PLCNEW+19.4K19.4K+$2M$2M
AVTRAVANTOR INCNEW+172.4K172.4K+$2M$2M
CLHCLEAN HARBORS INCNEW+9.1K9.1K+$2M$2M
LITELUMENTUM HLDGS INCNEW+12.9K12.9K+$2M$2M
FLSFLOWSERVE CORPNEW+39.0K39.0K+$2M$2M
COFCAPITAL ONE FINL CORPNEW+9.7K9.7K+$2M$2M

Value changes conflate price moves with buying and selling — share changes are the real signal. Share counts are not split-adjusted.

Holdings — Q3 2025

50 positions
Export to Excel
#IssuerClass% PortfolioValue ↓Shares
1DBCINVESCO DB COMMDY INDX TRCKhistory →UNIT7.93%$32M1.44M
2ABVXABIVAX SAhistory →SPONSORED ADS3.84%$16M184.5K
3MERUS N VCOM3.08%$13M133.3K
4VRDNVIRIDIAN THERAPEUTICS INChistory →COM2.48%$10M469.3K
5RVMDREVOLUTION MEDICINES INChistory →COM2.01%$8M175.4K
6PTGXPROTAGONIST THERAPEUTICS INChistory →COM1.98%$8M121.7K
7NUVLNUVALENT INChistory →COM1.98%$8M93.3K
8MLYSMINERALYS THERAPEUTICS INChistory →COM1.95%$8M209.8K
9ACLXGBXARCELLX INChistory →COMMON STOCK1.94%$8M96.2K
10AGIOAGIOS PHARMACEUTICALS INChistory →COM1.92%$8M195.3K
11CYTKCYTOKINETICS INChistory →COM NEW1.79%$7M132.9K
12IM8NINSMED INChistory →COM PAR $.011.76%$7M49.9K
13CDTXCIDARA THERAPEUTICS INChistory →COM NEW1.66%$7M70.9K
14COGTCOGENT BIOSCIENCES INChistory →COM1.63%$7M462.4K
15GPCRSTRUCTURE THERAPEUTICS INChistory →SPONSORED ADS1.62%$7M236.2K
16AMZNAMAZON COM INChistory →COM1.42%$6M26.4K
17SNDKSANDISK CORPhistory →COM1.31%$5M47.5K
18ELVNENLIVEN THERAPEUTICS INChistory →COM1.30%$5M259.1K
19AKROAKERO THERAPEUTICS INChistory →COM1.28%$5M110.1K
20PRAXPRAXIS PRECISION MEDICINES Ihistory →COM NEW1.23%$5M95.0K
21MSFTMICROSOFT CORPhistory →COM1.20%$5M9.5K
22OLMAOLEMA PHARMACEUTICALS INChistory →COM1.05%$4M437.2K
23BBIOBRIDGEBIO PHARMA INChistory →COM1.04%$4M82.0K
24APGEAPOGEE THERAPEUTICS INChistory →COM1.04%$4M107.1K
25IMVTIMMUNOVANT INChistory →COM1.00%$4M253.1K
26X0M1XOMA ROYALTY CORPORATIONCOM NEW1.00%$4M105.7K
27GHGUARDANT HEALTH INCCOM0.99%$4M64.6K
28LQDALIQUIDIA CORPORATIONCOM NEW0.98%$4M176.5K
29RYTMRHYTHM PHARMACEUTICALS INCCOM0.93%$4M37.5K
30SYRESPYRE THERAPEUTICS INCCOM NEW0.89%$4M215.7K
31TCE2CELLDEX THERAPEUTICS INC NEWCOM NEW0.86%$3M135.3K
32GH RESEARCH PLCORDINARY SHARES0.85%$3M241.9K
33EWTXEDGEWISE THERAPEUTICS INCCOM0.83%$3M208.1K
34AVGOBROADCOM INCCOM0.82%$3M10.2K
35METAMETA PLATFORMS INCCL A0.81%$3M4.5K
36XENEXENON PHARMACEUTICALS INCCOM0.81%$3M82.2K
37APLSUSDAPELLIS PHARMACEUTICALS INCCOM0.81%$3M145.7K
38PCVXVAXCYTE INCCOM0.77%$3M86.8K
39CRMSALESFORCE INCCOM0.75%$3M12.9K
40ARGXARGENX SESPONSORED ADR0.74%$3M4.1K
41RNAGBPAVIDITY BIOSCIENCES INCCOM0.70%$3M65.6K
42AMDADVANCED MICRO DEVICES INCCOM0.68%$3M17.2K
43XPOXPO INCCOM0.67%$3M21.1K
44UUNITY SOFTWARE INCCOM0.66%$3M67.2K
45VVISA INCCOM CL A0.66%$3M7.9K
46VERAVERA THERAPEUTICS INCCL A0.65%$3M91.2K
47CEGCONSTELLATION ENERGY CORPCOM0.61%$3M7.6K
48NVDANVIDIA CORPORATIONCOM0.61%$3M13.4K
49HPEHEWLETT PACKARD ENTERPRISE CCOM0.59%$2M98.7K
50MAMASTERCARD INCORPORATEDCL A0.59%$2M4.2K

Filing History

QuarterReported ValuePositionsFiledTypeLinks
Q1 2026$362M156May 15, 202613F-HRchanges · EDGAR ↗
Q4 2025$388M145Feb 17, 202613F-HRchanges · EDGAR ↗
Q3 2025$408M148Nov 14, 202513F-HRchanges · EDGAR ↗
Q2 2025$272M146Aug 14, 202513F-HRchanges · EDGAR ↗
Q1 2025$260M148May 15, 202513F-HRchanges · EDGAR ↗
Q4 2024$269M137Feb 14, 202513F-HRchanges · EDGAR ↗
Q3 2024$290M142Nov 14, 202413F-HRchanges · EDGAR ↗
Q2 2024$274M138Aug 14, 202413F-HRchanges · EDGAR ↗
Q1 2024$280M131May 15, 202413F-HRchanges · EDGAR ↗
Q4 2023$276M126Feb 14, 202413F-HRchanges · EDGAR ↗
Q3 2023$216M132Nov 14, 202313F-HRchanges · EDGAR ↗
Q2 2023$219M134Aug 14, 202313F-HRchanges · EDGAR ↗
Q1 2023$123M108May 15, 202313F-HRchanges · EDGAR ↗
Q4 2022$168M105Feb 14, 202313F-HRchanges · EDGAR ↗
Q3 2022$175M113Nov 14, 202213F-HRchanges · EDGAR ↗
Q2 2022$166M110Aug 15, 202213F-HRchanges · EDGAR ↗
Q1 2022$157M86May 16, 202213F-HRchanges · EDGAR ↗
Q4 2021$126M69Feb 14, 202213F-HRchanges · EDGAR ↗
Q3 2021$151M127Nov 15, 202113F-HRchanges · EDGAR ↗
Q2 2021$141M116Aug 16, 202113F-HRchanges · EDGAR ↗
Q1 2021$135M125May 17, 202113F-HRchanges · EDGAR ↗
Q4 2020$157M117Feb 16, 202113F-HRchanges · EDGAR ↗
Q3 2020$137M113Nov 16, 202013F-HRchanges · EDGAR ↗
Q2 2020$121M100Aug 14, 202013F-HRchanges · EDGAR ↗
Q1 2020$108M65May 15, 202013F-HRchanges · EDGAR ↗
Q4 2019$132M119Feb 14, 202013F-HRchanges · EDGAR ↗
Q3 2019$147M126Nov 14, 201913F-HRchanges · EDGAR ↗
Q2 2019$195M108Aug 14, 201913F-HRchanges · EDGAR ↗
Q1 2019$123M112May 15, 201913F-HRchanges · EDGAR ↗
Q4 2018$116M113Feb 14, 201913F-HRchanges · EDGAR ↗

Other Included Managers

This filing reports holdings on behalf of 1 additional manager.

  • HighVista Private Capital Management LLC

13F filings are due up to 45 days after quarter end, so holdings shown here lag the fund’s current book. Source: original SEC filing on EDGAR ↗.