SEC 13F Intelligence

Managers / Q4 2024 · view latest →

HighVista Strategies LLC

CIK 0001335325 · 200 CLARENDON STREET, 50TH FLOOR, BOSTON, MA, 02116 · 617-406-6500

Reported Value
$269M
Q4 2024
Positions
137
Filings on Record
30
2019–present window
Filed
Feb 14, 2025
original filing

Summary

Highvista Strategies LLC reported $269M in U.S.-listed holdings across 137 positions for Q4 2024.

Its largest position, DBC, represents 11.4% of the portfolio.

Compared with Q3 2024, the fund opened 26 new positions and exited 31.

Portfolio Metrics

Turnover
+21.8%
vs prior filed quarter
Top-10 Concentration
+26.3%
share of reported value
Largest Position
+11.4%
Invesco Db Commdy Indx Trck
New / Exited
26 / 31
positions this quarter

Methodology: turnover is min(value bought, value sold) ÷ average reported value across the two quarters — value-based, so market moves inflate it slightly versus a share-based measure. Concentration and largest position are shares of the filing’s total reported value, options excluded. New/exited counts compare against the prior filed quarter. All figures derive solely from the fund’s 13F filings.

Reported Value by Quarter

13F Reported Value
Q4 ’18: $116MQ4 ’18Q1 ’19: $123MQ2 ’19: $195MQ3 ’19: $147MQ4 ’19: $132MQ4 ’19Q1 ’20: $108MQ2 ’20: $121MQ3 ’20: $137MQ4 ’20: $157MQ4 ’20Q1 ’21: $135MQ2 ’21: $141MQ3 ’21: $151MQ4 ’21: $126MQ4 ’21Q1 ’22: $157MQ2 ’22: $166MQ3 ’22: $175MQ4 ’22: $168MQ4 ’22Q1 ’23: $123MQ2 ’23: $219MQ3 ’23: $216MQ4 ’23: $276MQ4 ’23Q1 ’24: $280MQ2 ’24: $274MQ3 ’24: $290MQ4 ’24: $269MQ4 ’24Q1 ’25: $260MQ2 ’25: $272MQ3 ’25: $408MQ4 ’25: $388MQ4 ’25Q1 ’26: $362Mfilingsflow.com

Portfolio Composition

By security type
Common Stock: 74.3%ETP: 11.4%ADR: 8.5%Other: 5.7%
  • Common Stock · 74.3% · $200M
  • ETP · 11.4% · $31M
  • ADR · 8.5% · $23M
  • Other · 5.7% · $15M

Quarter-over-Quarter Changes full breakdown →

vs Q3 2024 (amended baseline)

IssuerMoveShare ΔShares nowValue ΔValue now
METAMETA PLATFORMS INCNEW+5.3K5.3K+$3M$3M
GHGUARDANT HEALTH INCNEW+94.1K94.1K+$3M$3M
UALUNITED AIRLS HLDGS INCNEW+17.8K17.8K+$2M$2M
ALKERMES PLCNEW+54.4K54.4K+$2M$2M
CIENCIENA CORPNEW+18.4K18.4K+$2M$2M
CPNGCOUPANG INCNEW+69.7K69.7K+$2M$2M
WRBYWARBY PARKER INCNEW+62.0K62.0K+$2M$2M
AALAMERICAN AIRLS GROUP INCNEW+86.1K86.1K+$2M$2M

Value changes conflate price moves with buying and selling — share changes are the real signal. Share counts are not split-adjusted.

Holdings — Q4 2024

50 positions
Export to Excel
#IssuerClass% PortfolioValue ↓Shares
1DBCINVESCO DB COMMDY INDX TRCKhistory →UNIT11.42%$31M1.44M
2AMZNAMAZON COM INChistory →COM2.79%$8M34.2K
3HCP2EURHASHICORP INChistory →COM CL A1.66%$4M130.2K
4MSFTMICROSOFT CORPhistory →COM1.66%$4M10.6K
5AKXANSYS INChistory →COM1.61%$4M12.8K
6JNPJUNIPER NETWORKS INChistory →COM1.60%$4M114.7K
7HESHESS CORPhistory →COM1.43%$4M28.9K
8DVAXDYNAVAX TECHNOLOGIES CORPhistory →COM NEW1.42%$4M298.5K
9JANXJANUX THERAPEUTICS INChistory →COM1.39%$4M69.7K
10ACIALBERTSONS COS INChistory →COMMON STOCK1.38%$4M188.8K
11PCVXVAXCYTE INChistory →COM1.36%$4M44.7K
12AMEDAMEDISYS INChistory →COM1.33%$4M39.3K
13ARGXARGENX SEhistory →SPONSORED ADR1.31%$4M5.7K
14APLSUSDAPELLIS PHARMACEUTICALS INChistory →COM1.29%$3M108.7K
15XPOXPO INChistory →COM1.26%$3M25.8K
16ACLXGBXARCELLX INChistory →COMMON STOCK1.25%$3M43.8K
17BKNGBOOKING HOLDINGS INChistory →COM1.21%$3M657
18CRMSALESFORCE INChistory →COM1.19%$3M9.6K
19NUVLNUVALENT INChistory →COM1.16%$3M39.9K
20METAMETA PLATFORMS INChistory →CL A1.15%$3M5.3K
21X0M1XOMA ROYALTY CORPORATIONhistory →COM NEW1.12%$3M114.5K
22VRDNVIRIDIAN THERAPEUTICS INChistory →COM1.10%$3M154.6K
23GHGUARDANT HEALTH INChistory →COM1.07%$3M94.1K
24GEHCGE HEALTHCARE TECHNOLOGIES Ihistory →COMMON STOCK1.02%$3M35.0K
25XENEXENON PHARMACEUTICALS INCCOM0.97%$3M66.8K
26ELVNENLIVEN THERAPEUTICS INCCOM0.94%$3M112.5K
27GOOGALPHABET INCCAP STK CL C0.94%$3M13.2K
28RVMDREVOLUTION MEDICINES INCCOM0.93%$3M57.2K
29SWTXUSDSPRINGWORKS THERAPEUTICS INCCOM0.92%$2M68.8K
30PTGXPROTAGONIST THERAPEUTICS INCCOM0.90%$2M62.5K
31LQDALIQUIDIA CORPORATIONCOM NEW0.89%$2M203.5K
32MLTXMOONLAKE IMMUNOTHERAPEUTICSCLASS A ORD0.88%$2M43.5K
33MERUS N VCOM0.86%$2M55.0K
34GEVGE VERNOVA INCCOM0.83%$2M6.8K
35TEVATEVA PHARMACEUTICAL INDS LTDSPONSORED ADS0.83%$2M101.3K
36SYRESPYRE THERAPEUTICS INCCOM NEW0.82%$2M95.2K
37EWTXEDGEWISE THERAPEUTICS INCCOM0.82%$2M82.7K
38VERAVERA THERAPEUTICS INCCL A0.82%$2M52.2K
39TSMTAIWAN SEMICONDUCTOR MFG LTDSPONSORED ADS0.82%$2M11.1K
40COGTCOGENT BIOSCIENCES INCCOM0.81%$2M279.7K
41AVGOBROADCOM INCCOM0.78%$2M9.1K
42RYTMRHYTHM PHARMACEUTICALS INCCOM0.78%$2M37.4K
43VVISA INCCOM CL A0.76%$2M6.4K
44LYVLIVE NATION ENTERTAINMENT INCOM0.75%$2M15.6K
45APGEAPOGEE THERAPEUTICS INCCOM0.73%$2M43.2K
46IM8NINSMED INCCOM PAR $.010.71%$2M27.6K
47DYNDYNE THERAPEUTICS INCCOM0.69%$2M78.4K
48INDIVIOR PLCORD0.68%$2M142.6K
49BABAALIBABA GROUP HLDG LTDSPONSORED ADS0.66%$2M20.9K
50CSCOCISCO SYS INCCOM0.65%$2M29.6K

Filing History

QuarterReported ValuePositionsFiledTypeLinks
Q1 2026$362M156May 15, 202613F-HRchanges · EDGAR ↗
Q4 2025$388M145Feb 17, 202613F-HRchanges · EDGAR ↗
Q3 2025$408M148Nov 14, 202513F-HRchanges · EDGAR ↗
Q2 2025$272M146Aug 14, 202513F-HRchanges · EDGAR ↗
Q1 2025$260M148May 15, 202513F-HRchanges · EDGAR ↗
Q4 2024$269M137Feb 14, 202513F-HRchanges · EDGAR ↗
Q3 2024$290M142Nov 14, 202413F-HRchanges · EDGAR ↗
Q2 2024$274M138Aug 14, 202413F-HRchanges · EDGAR ↗
Q1 2024$280M131May 15, 202413F-HRchanges · EDGAR ↗
Q4 2023$276M126Feb 14, 202413F-HRchanges · EDGAR ↗
Q3 2023$216M132Nov 14, 202313F-HRchanges · EDGAR ↗
Q2 2023$219M134Aug 14, 202313F-HRchanges · EDGAR ↗
Q1 2023$123M108May 15, 202313F-HRchanges · EDGAR ↗
Q4 2022$168M105Feb 14, 202313F-HRchanges · EDGAR ↗
Q3 2022$175M113Nov 14, 202213F-HRchanges · EDGAR ↗
Q2 2022$166M110Aug 15, 202213F-HRchanges · EDGAR ↗
Q1 2022$157M86May 16, 202213F-HRchanges · EDGAR ↗
Q4 2021$126M69Feb 14, 202213F-HRchanges · EDGAR ↗
Q3 2021$151M127Nov 15, 202113F-HRchanges · EDGAR ↗
Q2 2021$141M116Aug 16, 202113F-HRchanges · EDGAR ↗
Q1 2021$135M125May 17, 202113F-HRchanges · EDGAR ↗
Q4 2020$157M117Feb 16, 202113F-HRchanges · EDGAR ↗
Q3 2020$137M113Nov 16, 202013F-HRchanges · EDGAR ↗
Q2 2020$121M100Aug 14, 202013F-HRchanges · EDGAR ↗
Q1 2020$108M65May 15, 202013F-HRchanges · EDGAR ↗
Q4 2019$132M119Feb 14, 202013F-HRchanges · EDGAR ↗
Q3 2019$147M126Nov 14, 201913F-HRchanges · EDGAR ↗
Q2 2019$195M108Aug 14, 201913F-HRchanges · EDGAR ↗
Q1 2019$123M112May 15, 201913F-HRchanges · EDGAR ↗
Q4 2018$116M113Feb 14, 201913F-HRchanges · EDGAR ↗

Other Included Managers

This filing reports holdings on behalf of 1 additional manager.

  • HighVista Private Capital Management LLC

13F filings are due up to 45 days after quarter end, so holdings shown here lag the fund’s current book. Source: original SEC filing on EDGAR ↗.