SEC 13F Intelligence

Managers / Q1 2023 · view latest →

HighVista Strategies LLC

CIK 0001335325 · 200 CLARENDON STREET, 50TH FLOOR, BOSTON, MA, 02116 · 617-406-6500

Reported Value
$123M
Q1 2023
Positions
108
Filings on Record
30
2019–present window
Filed
May 15, 2023
original filing

Summary

Highvista Strategies LLC reported $123M in U.S.-listed holdings across 108 positions for Q1 2023.

Its largest position, SGENUSD, represents 3.6% of the portfolio.

Compared with Q4 2022, the fund opened 37 new positions and exited 34.

Portfolio Metrics

Turnover
+28.0%
vs prior filed quarter
Top-10 Concentration
+29.1%
share of reported value
Largest Position
+3.6%
Seagen
New / Exited
37 / 34
positions this quarter

Methodology: turnover is min(value bought, value sold) ÷ average reported value across the two quarters — value-based, so market moves inflate it slightly versus a share-based measure. Concentration and largest position are shares of the filing’s total reported value, options excluded, with multiple share classes and repeated sub-manager rows for the same issuer combined into one position — the same rule the holdings table uses by default. New/exited counts compare against the prior filed quarter. All figures derive solely from the fund’s 13F filings.

Reported Value by Quarter

13F Reported Value
Q4 ’18: $116MQ4 ’18Q1 ’19: $123MQ2 ’19: $195MQ3 ’19: $147MQ4 ’19: $132MQ4 ’19Q1 ’20: $108MQ2 ’20: $121MQ3 ’20: $137MQ4 ’20: $157MQ4 ’20Q1 ’21: $135MQ2 ’21: $141MQ3 ’21: $151MQ4 ’21: $126MQ4 ’21Q1 ’22: $157MQ2 ’22: $166MQ3 ’22: $175MQ4 ’22: $168MQ4 ’22Q1 ’23: $123MQ2 ’23: $219MQ3 ’23: $216MQ4 ’23: $276MQ4 ’23Q1 ’24: $280MQ2 ’24: $274MQ3 ’24: $290MQ4 ’24: $269MQ4 ’24Q1 ’25: $260MQ2 ’25: $272MQ3 ’25: $408MQ4 ’25: $388MQ4 ’25Q1 ’26: $362Mfilingsflow.com

Portfolio Composition

By security type
Common Stock: 81.2%Other: 9.0%ADR: 5.5%ETP: 4.3%
  • Common Stock · 81.2% · $100M
  • Other · 9.0% · $11M
  • ADR · 5.5% · $7M
  • ETP · 4.3% · $5M

Quarter-over-Quarter Changes full breakdown →

vs Q4 2022 (amended baseline)

IssuerMoveShare ΔShares nowValue ΔValue now
OAK STR HEALTH INCNEW+89.4K89.4K+$3M$3M
ACIALBERTSONS COS INCNEW+154.0K154.0K+$3M$3M
HORIZON THERAPEUTICS PUB LNEW+29.0K29.0K+$3M$3M
MLTXMOONLAKE IMMUNOTHERAPEUTICSNEW+122.2K122.2K+$3M$3M
IMVTIMMUNOVANT INCNEW+163.8K163.8K+$3M$3M
X0M1XOMA CORP DELNEW+93.4K93.4K+$2M$2M
ACLXGBXARCELLX INCNEW+54.3K54.3K+$2M$2M
MERUS N VNEW+46.0K46.0K+$845,609$845,609

Value changes conflate price moves with buying and selling — share changes are the real signal. Share counts are not split-adjusted.

Holdings — Q1 2023

108 positions
Export to Excel
#IssuerClass% PortfolioValue ↓Shares
1SGENUSDSEAGEN INChistory →COM3.62%$4M21.9K
2ISHARES TRRUS 1000 VAL ETF3.46%$4M27.9K
3CPNGCOUPANG INChistory →CL A3.34%$4M256.3K
4AXSMAXSOME THERAPEUTICS INChistory →COM3.05%$4M60.8K
5OAK STR HEALTH INCCOM2.82%$3M89.4K
6ATVIEURACTIVISION BLIZZARD INChistory →COM2.79%$3M40.0K
7ACIALBERTSONS COS INChistory →COMMON STOCK2.61%$3M154.0K
8HORIZON THERAPEUTICS PUB LSHS2.58%$3M29.0K
9CYMABAY THERAPEUTICS INCCOM2.47%$3M347.8K
10VMWEURVMWARE INChistory →CL A COM2.40%$3M23.6K
11TVTXTRAVERE THERAPEUTICS INChistory →COM2.23%$3M121.8K
12MLTXMOONLAKE IMMUNOTHERAPEUTICShistory →CLASS A ORD2.13%$3M122.2K
13APLSUSDAPELLIS PHARMACEUTICALS INChistory →COM2.10%$3M39.1K
14IMVTIMMUNOVANT INChistory →COM2.07%$3M163.8K
15TGNATEGNA INChistory →COM1.98%$2M144.0K
16BKIEURBLACK KNIGHT INChistory →COM1.98%$2M42.2K
17VRDNVIRIDIAN THERAPEUTICS INChistory →COM1.97%$2M94.9K
18FT2FIRST HORIZON CORPORATIONhistory →COM1.96%$2M135.4K
19OPHTEURIVERIC BIO INChistory →COM1.94%$2M98.1K
20PROMETHEUS BIOSCIENCES INCCOM1.83%$2M21.0K
21RLAYRELAY THERAPEUTICS INChistory →COM1.73%$2M129.2K
22COGTCOGENT BIOSCIENCES INChistory →COM1.62%$2M184.0K
23X0M1XOMA CORP DELhistory →COM NEW1.61%$2M93.4K
24BCYCBICYCLE THERAPEUTICS PLChistory →SPONSORED ADS1.60%$2M92.4K
25DICE THERAPEUTICS INCCOM1.57%$2M67.4K
26430TERNS PHARMACEUTICALS INChistory →COM1.42%$2M146.9K
27ACLXGBXARCELLX INChistory →COMMON STOCK1.36%$2M54.3K
28RPTXREPARE THERAPEUTICS INChistory →COM1.32%$2M164.9K
29ACRSACLARIS THERAPEUTICS INChistory →COM1.30%$2M197.8K
30DYNDYNE THERAPEUTICS INCCOM0.96%$1M102.4K
31CHINOOK THERAPEUTICS INCCOM0.93%$1M49.5K
32CRMSALESFORCE INCCOM0.91%$1M5.6K
33SRPTSAREPTA THERAPEUTICS INCCOM0.87%$1M7.7K
34MSFTMICROSOFT CORPCOM0.85%$1M3.6K
35ACADACADIA PHARMACEUTICALS INCCOM0.85%$1M55.6K
36DBCINVESCO DB COMMDY INDX TRCKUNIT0.82%$1M42.4K
37VRNAVERONA PHARMA PLCSPONSORED ADS0.78%$958,27847.7K
38BMRNBIOMARIN PHARMACEUTICAL INCCOM0.77%$943,3259.7K
39XENEXENON PHARMACEUTICALS INCCOM0.74%$906,91925.3K
40PLRXPLIANT THERAPEUTICS INCCOM0.74%$905,33134.0K
41TCE2CELLDEX THERAPEUTICS INC NEWCOM NEW0.73%$890,21724.7K
42KRYSKRYSTAL BIOTECH INCCOM0.72%$885,30311.1K
43GOOGALPHABET INCCAP STK CL C0.72%$884,0008.5K
44ARGXARGENX SESPONSORED ADR0.71%$869,2292.3K
45AM6AMICUS THERAPEUTICS INCCOM0.70%$857,41277.3K
46MERUS N VCOM0.69%$845,60946.0K
47ALNYALNYLAM PHARMACEUTICALS INCCOM0.66%$812,4984.1K
48PTCTPTC THERAPEUTICS INCCOM0.65%$800,95516.5K
49VTYXUSDVENTYX BIOSCIENCES INCCOM0.64%$790,03123.6K
50ASCENDIS PHARMA A/SSPONSORED ADR0.64%$786,7807.3K
51INCYINCYTE CORPCOM0.64%$786,22510.9K
52CRNXCRINETICS PHARMACEUTICALS INCOM0.63%$774,81548.2K
53BIIBBIOGEN INCCOM0.62%$762,6362.7K
54KYMRKYMERA THERAPEUTICS INCCOM0.62%$756,45425.5K
55VVISA INCCOM CL A0.61%$753,0373.3K
56AMARIN CORP PLCSPONS ADR NEW0.61%$751,020500.7K
57PCVXVAXCYTE INCCOM0.60%$734,83319.6K
58UTHUNITED THERAPEUTICS CORP DELCOM0.58%$717,5683.2K
59AKROAKERO THERAPEUTICS INCCOM0.58%$712,74618.6K
60PROTHENA CORP PLCSHS0.58%$706,30514.6K
61NVLSEURALPINE IMMUNE SCIENCES INCCOM0.57%$697,01690.3K
62AMZNAMAZON COM INCCOM0.55%$678,6156.6K
63MDGLMADRIGAL PHARMACEUTICALS INCCOM0.55%$677,3592.8K
64IMCRIMMUNOCORE HLDGS PLCADS0.53%$652,31113.2K
65FISVFISERV INCCOM0.52%$642,2375.7K
66RYTMRHYTHM PHARMACEUTICALS INCCOM0.52%$632,92835.5K
67MAMASTERCARD INCORPORATEDCL A0.49%$606,8941.7K
68MRTXEURMIRATI THERAPEUTICS INCCOM0.48%$585,13915.7K
69ANABANAPTYSBIO INCCOM0.45%$548,76525.2K
70INTUINTUITCOM0.44%$543,9131.2K
71SNDXSYNDAX PHARMACEUTICALS INCCOM0.44%$540,75625.6K
72ARVNARVINAS INCCOM0.43%$524,46219.2K
73BLUBELLUS HEALTH INC NEWCOM NEW0.40%$491,70268.3K
74ENDEAVOR GROUP HLDGS INCCL A COM0.37%$458,49919.2K
75SWTXUSDSPRINGWORKS THERAPEUTICS INCCOM0.37%$454,23417.6K
76BKNGBOOKING HOLDINGS INCCOM0.35%$424,386160
77LEGNLEGEND BIOTECH CORPSPONSORED ADS0.33%$407,0738.4K
78WDAYWORKDAY INCCL A0.30%$363,5111.8K
79JDJD.COM INCSPON ADR CL A0.29%$359,0208.2K
80KURAKURA ONCOLOGY INCCOM0.29%$357,63029.2K
81BILIBILIBILI INCSPONS ADS REP Z0.29%$352,26515.0K
82NUVLNUVALENT INCCOM0.28%$344,51813.2K
83LPLALPL FINL HLDGS INCCOM0.28%$344,0801.7K
84TMUST-MOBILE US INCCOM0.27%$334,5802.3K
85TECK/BTECK RESOURCES LTDCL B0.27%$333,9759.2K
86EXECHESAPEAKE ENERGY CORPCOM0.27%$333,8164.4K
87PTCPTC INCCOM0.27%$328,2692.6K
88ROPROPER TECHNOLOGIES INCCOM0.26%$321,704730
89AEROVATE THERAPEUTICS INCCOM0.26%$319,35215.8K
90LAURLAUREATE EDUCATION INCCOMMON STOCK0.25%$304,58425.9K
91REPLREPLIMUNE GROUP INCCOM0.25%$304,29917.2K
92WCCWESCO INTL INCCOM0.23%$287,4441.9K
93MSCIMSCI INCCOM0.23%$279,845500
94BABAALIBABA GROUP HLDG LTDSPONSORED ADS0.22%$271,7992.7K
95IBNICICI BANK LIMITEDADR0.21%$262,41312.2K
96AG8AGILENT TECHNOLOGIES INCCOM0.21%$261,4621.9K
97RNAGBPAVIDITY BIOSCIENCES INCCOM0.21%$256,85216.7K
98HDBHDFC BANK LTDSPONSORED ADS0.20%$250,0133.8K
99TRUTRANSUNIONCOM0.20%$247,3184.0K
100FERGUSON PLC NEWSHS0.20%$246,1001.8K

Filing History

QuarterReported ValuePositionsFiledTypeLinks
Q1 2026$362M156May 15, 202613F-HRchanges · EDGAR ↗
Q4 2025$388M145Feb 17, 202613F-HRchanges · EDGAR ↗
Q3 2025$408M148Nov 14, 202513F-HRchanges · EDGAR ↗
Q2 2025$272M146Aug 14, 202513F-HRchanges · EDGAR ↗
Q1 2025$260M148May 15, 202513F-HRchanges · EDGAR ↗
Q4 2024$269M137Feb 14, 202513F-HRchanges · EDGAR ↗
Q3 2024$290M142Nov 14, 202413F-HRchanges · EDGAR ↗
Q2 2024$274M138Aug 14, 202413F-HRchanges · EDGAR ↗
Q1 2024$280M131May 15, 202413F-HRchanges · EDGAR ↗
Q4 2023$276M126Feb 14, 202413F-HRchanges · EDGAR ↗
Q3 2023$216M132Nov 14, 202313F-HRchanges · EDGAR ↗
Q2 2023$219M134Aug 14, 202313F-HRchanges · EDGAR ↗
Q1 2023$123M108May 15, 202313F-HRchanges · EDGAR ↗
Q4 2022$168M105Feb 14, 202313F-HRchanges · EDGAR ↗
Q3 2022$175M113Nov 14, 202213F-HRchanges · EDGAR ↗
Q2 2022$166M110Aug 15, 202213F-HRchanges · EDGAR ↗
Q1 2022$157M86May 16, 202213F-HRchanges · EDGAR ↗
Q4 2021$126M69Feb 14, 202213F-HRchanges · EDGAR ↗
Q3 2021$151M127Nov 15, 202113F-HRchanges · EDGAR ↗
Q2 2021$141M116Aug 16, 202113F-HRchanges · EDGAR ↗
Q1 2021$135M125May 17, 202113F-HRchanges · EDGAR ↗
Q4 2020$157M117Feb 16, 202113F-HRchanges · EDGAR ↗
Q3 2020$137M113Nov 16, 202013F-HRchanges · EDGAR ↗
Q2 2020$121M100Aug 14, 202013F-HRchanges · EDGAR ↗
Q1 2020$108M65May 15, 202013F-HRchanges · EDGAR ↗
Q4 2019$132M119Feb 14, 202013F-HRchanges · EDGAR ↗
Q3 2019$147M126Nov 14, 201913F-HRchanges · EDGAR ↗
Q2 2019$195M108Aug 14, 201913F-HRchanges · EDGAR ↗
Q1 2019$123M112May 15, 201913F-HRchanges · EDGAR ↗
Q4 2018$116M113Feb 14, 201913F-HRchanges · EDGAR ↗

13F filings are due up to 45 days after quarter end, so holdings shown here lag the fund’s current book. Source: original SEC filing on EDGAR ↗.