SEC 13F Intelligence

Managers / Q4 2022 · view latest →

SECTORAL ASSET MANAGEMENT INC

CIK 0001274413 · 1010 SHERBROOKE ST., WEST, SUITE 1610, MONTREAL, A8, H3A 2R7 · 514 849 8777

Reported Value
$517M
Q4 2022
Positions
120
Filings on Record
30
2019–present window
Filed
Feb 10, 2023
original filing

Summary

Sectoral Asset Management Inc reported $517M in U.S.-listed holdings across 120 positions for Q4 2022.

Its largest position, EVH, represents 3.2% of the portfolio.

Compared with Q3 2022, the fund opened 22 new positions and exited 11.

Portfolio Metrics

Turnover
+17.5%
vs prior filed quarter
Top-10 Concentration
+25.2%
share of reported value
Largest Position
+3.2%
Evolent Health
New / Exited
22 / 11
positions this quarter

Methodology: turnover is min(value bought, value sold) ÷ average reported value across the two quarters — value-based, so market moves inflate it slightly versus a share-based measure. Concentration and largest position are shares of the filing’s total reported value, options excluded, with multiple share classes and repeated sub-manager rows for the same issuer combined into one position — the same rule the holdings table uses by default. New/exited counts compare against the prior filed quarter. All figures derive solely from the fund’s 13F filings.

Reported Value by Quarter

13F Reported Value
Q4 ’18: $736MQ4 ’18Q1 ’19: $831MQ2 ’19: $836MQ3 ’19: $580MQ4 ’19: $670MQ4 ’19Q1 ’20: $521MQ2 ’20: $1.1BQ3 ’20: $1.2BQ4 ’20: $1.4BQ4 ’20Q1 ’21: $1.3BQ2 ’21: $1.2BQ3 ’21: $1.2BQ4 ’21: $664MQ4 ’21Q1 ’22: $563MQ2 ’22: $496MQ3 ’22: $508MQ4 ’22: $517MQ4 ’22Q1 ’23: $520MQ2 ’23: $600MQ3 ’23: $514MQ4 ’23: $232MQ4 ’23Q1 ’24: $254MQ2 ’24: $246MQ3 ’24: $169MQ4 ’24: $150MQ4 ’24Q1 ’25: $128MQ2 ’25: $151MQ3 ’25: $162MQ4 ’25: $125MQ4 ’25Q1 ’26: $121Mfilingsflow.com

Portfolio Composition

By security type
Common Stock: 92.2%Other: 6.3%ADR: 1.3%ETP: 0.2%
  • Common Stock · 92.2% · $477M
  • Other · 6.3% · $32M
  • ADR · 1.3% · $7M
  • ETP · 0.2% · $1M

Quarter-over-Quarter Changes full breakdown →

vs Q3 2022 (amended baseline)

IssuerMoveShare ΔShares nowValue ΔValue now
OPCHOPTION CARE HEALTHNEW+273.5K273.5K+$8M$8M
PRTAPROTHENA CORP PLCNEW+115.2K115.2K+$7M$7M
ALHCALIGNMENT HEALTHCANEW+549.0K549.0K+$6M$6M
RDNTRADNET INCNEW+296.9K296.9K+$6M$6M
REPLREPLIMUNE GROUP INCNEW+196.5K196.5K+$5M$5M
PCVXVAXCYTE INCNEW+60.0K60.0K+$3M$3M
GRTXGALERA THERAPEUTICNEW+1.67M1.67M+$2M$2M
EWEDWARDS LIFESCIENCENEW+31.9K31.9K+$2M$2M

Value changes conflate price moves with buying and selling — share changes are the real signal. Share counts are not split-adjusted.

Holdings — Q4 2022

120 positions
Export to Excel
#IssuerClass% PortfolioValue ↓Shares
1EVHEVOLENT HEALTH INChistory →CL A3.18%$16M585.6K
2HQYHEALTHEQUITY INChistory →COM2.91%$15M243.8K
3R1 RCM INCCOM2.87%$15M1.35M
4BMRNBIOMARIN PHARMAC INChistory →COM2.78%$14M138.8K
5UNHUNITEDHEALTH GRP INChistory →COM2.59%$13M25.3K
6PROMETHEUS BIOSCIENCCOM2.39%$12M112.2K
7INARI MED INCCOM2.22%$11M180.7K
8ICLRICON PLChistory →SHS2.13%$11M56.6K
9JNJJOHNSON & JOHNSONhistory →COM2.12%$11M62.1K
10INSMINSMED INChistory →COM2.00%$10M516.1K
11ATRCATRICURE INChistory →COM1.95%$10M226.5K
12IRTCIRHYTHM TECHNOLOGIEShistory →COM1.74%$9M96.1K
13EXELEXELIXIS INChistory →COM1.72%$9M553.5K
14PTCTPTC THERAPEUTICS Ihistory →COM1.68%$9M227.5K
15OPCHOPTION CARE HEALTHhistory →COM1.59%$8M273.5K
16ARVNARVINAS INChistory →COM1.58%$8M239.2K
17AGILITI INCCOM1.57%$8M498.2K
18SHOCKWAVE MEDICALCOM1.56%$8M39.1K
19APELLIS PHARMACEUTICCOM1.52%$8M152.3K
20HALOHALOZYME THERAPEUTIChistory →COM1.51%$8M137.4K
21PRVAPRIVIA HEALTH GROUPhistory →COM1.41%$7M321.3K
22PRTAPROTHENA CORP PLChistory →SHS1.34%$7M115.2K
23DNLIDENALI THERAPEUTICShistory →COM1.31%$7M243.8K
24LNTHLANTHEUS HLDGS INChistory →COM1.31%$7M132.7K
25LLYLILLY ELI & COhistory →COM1.30%$7M18.4K
26SPRYARS PHARMACEUTICALShistory →COM1.29%$7M782.4K
27PFEPFIZER INChistory →COM1.28%$7M129.4K
28INTRA CELLULAR THERACOM1.25%$6M122.5K
29ALHCALIGNMENT HEALTHCAhistory →COM1.25%$6M549.0K
30AMICUS THERAPEUTICSCOM1.20%$6M507.7K
31TVTXTRAVERE THERAPEUTICShistory →COM1.19%$6M292.3K
32MRKMERCK & CO INChistory →COM1.18%$6M55.0K
33ALKSALKERMES PLChistory →SHS1.17%$6M231.9K
34ABBVABBVIE INChistory →COM1.17%$6M37.3K
35CTI BIOPHARMA CORPCOM1.14%$6M980.3K
36AMLXAMYLYX PHARMACEUTIChistory →COM1.13%$6M157.9K
37ALTALTIMMUNE INChistory →COM1.09%$6M342.5K
38RDNTRADNET INChistory →COM1.08%$6M296.9K
39BLUBELLUS HEALTH INChistory →COM NEW1.06%$5M669.0K
40AXONICS INCCOM1.06%$5M87.6K
41ALNYALNYLAM PHARMACUETCLhistory →COM1.05%$5M22.8K
42REPLREPLIMUNE GROUP INChistory →COM1.03%$5M196.5K
43BSXBOSTON SCIENTIFIChistory →COM1.02%$5M114.0K
44SEAGEN INCCOM1.00%$5M40.2K
45BLUEPRINT MEDICINESCOM0.98%$5M115.9K
46THCTENET HEALTHCARECOM0.96%$5M101.5K
47RCUSARCUS BIOSCIENCESCOM0.95%$5M238.5K
48AMGNAMGEN INCCOM0.91%$5M17.9K
49INSPINSPIRE MED SYS INCCOM0.89%$5M18.2K
50SILK ROAD MEDICALCOM0.87%$4M84.6K
51TMOTHERMO FISHER SCICOM0.85%$4M8.0K
52KARUNA THERAPEUTICSCOM0.83%$4M21.8K
53TMCITREACE MED CONCEPTCOM0.80%$4M179.9K
54RALLYBIO CORPCOM0.79%$4M619.9K
55ZNTLZENTALIS PHARMACEUCOM0.78%$4M201.0K
56IMMUNOGEN INCCOM0.77%$4M803.9K
57ARWRARROWHEAD PHARMACEUTCOM0.75%$4M95.4K
58CYTKCYTOKINETICS INCCOM0.74%$4M83.5K
59RCKTROCKET PHARMACEUTICACOM0.72%$4M190.8K
60BIIBBIOGEN INCCOM0.72%$4M13.4K
61OMGBPOUTSET MED INCCOM0.70%$4M140.0K
62BMYBRISTOL MYERS SQUIBBCOM0.70%$4M50.0K
63OLMAOLEMA PHARMACEUTICALCOM0.68%$4M1.44M
64ABTABBOTT LABSCOM0.67%$3M31.7K
65MRNAMODERNA INCCOM USD0.62%$3M17.7K
66IQVIQVIA HOLDINGS INCCOM0.60%$3M15.1K
67DHRDANAHER CORPCOM0.60%$3M11.6K
68MIRATI THERAPEUTICSCOM0.59%$3M66.8K
69ARQTARCUTIS BIOTHERAPECOM0.58%$3M203.9K
70PCVXVAXCYTE INCCOM0.56%$3M60.0K
71NTLAINTELLIA THERAPEUTCOM0.48%$2M71.4K
72BEAMBEAM THERAPEUTICSCOM0.48%$2M63.5K
73GRTXGALERA THERAPEUTICCOM0.48%$2M1.67M
74MDTMEDTRONIC PLCSHS0.47%$2M31.6K
75EWEDWARDS LIFESCIENCECOM0.46%$2M31.9K
76SYKSTRYKER CORPCOM0.44%$2M9.3K
77GILDGILEAD SCIENCES INCCOM0.43%$2M26.1K
78STAASTAAR SURGICAL COCOM0.41%$2M44.0K
79VRTXVERTEX PHARMACEUTICLCOM0.39%$2M7.0K
80REGNREGENERON PHARMCTCLSCOM0.38%$2M2.7K
81FATEFATE THERAPEUTICSCOM0.36%$2M183.0K
82HUMHUMANA INCCOM0.35%$2M3.6K
83ZYMEZYMEWORKS INCCOM0.29%$2M192.1K
84EXSCIENTIA PLCADS0.27%$1M265.1K
85SRRKSCHOLAR ROCK HLDGCOM0.26%$1M151.2K
86AZNNASTRAZENECASP ADR0.26%$1M20.0K
87AVIRATEA PHARMACEUTICALSCOM0.26%$1M281.4K
88POINT BIOPHARMA GBLCOM0.26%$1M185.3K
89MGNXMACROGENICS INCCOM0.26%$1M200.2K
90ONCBEIGENE LIMITEDSP ADR0.25%$1M6.0K
91BIOXCEL THERAPEUTICOM0.25%$1M61.2K
92XBISPDR SER TRS&P BIOTECH0.25%$1M15.5K
93FDMT4D MOLECULAR THERACOM0.23%$1M53.8K
94BIOATLA INCCOM0.22%$1M138.3K
95ITEOS THERAPEUTICSCOM0.22%$1M57.8K
96GENERATION BIO COCOM0.21%$1M273.8K
97EFFECTOR THERAPEUTCSCOM0.20%$1M2.38M
98ILMNILLUMINA INCCOM0.18%$934,1644.6K
99HORIZON THERAPEUTICSSHS0.15%$773,8406.8K
100INCYINCYTE CORPORATIONCOM0.10%$536,5386.7K

Filing History

QuarterReported ValuePositionsFiledTypeLinks
Q1 2026$121M77May 15, 202613F-HRchanges · EDGAR ↗
Q4 2025$125M74Feb 9, 202613F-HRchanges · EDGAR ↗
Q3 2025$162M82Nov 14, 202513F-HRchanges · EDGAR ↗
Q2 2025$151M94Aug 14, 202513F-HRchanges · EDGAR ↗
Q1 2025$128M84May 15, 202513F-HRchanges · EDGAR ↗
Q4 2024$150M86Feb 14, 202513F-HRchanges · EDGAR ↗
Q3 2024$169M90Nov 14, 202413F-HRchanges · EDGAR ↗
Q2 2024$246M97Aug 13, 202413F-HRchanges · EDGAR ↗
Q1 2024$254M92May 14, 202413F-HRchanges · EDGAR ↗
Q4 2023$232M104Feb 14, 202413F-HRchanges · EDGAR ↗
Q3 2023$514M123Nov 14, 202313F-HRchanges · EDGAR ↗
Q2 2023$600M121Aug 11, 202313F-HRchanges · EDGAR ↗
Q1 2023$520M118May 12, 202313F-HRchanges · EDGAR ↗
Q4 2022$517M120Feb 10, 202313F-HRchanges · EDGAR ↗
Q3 2022$508M109Nov 10, 202213F-HRchanges · EDGAR ↗
Q2 2022$496M112Aug 15, 202213F-HRchanges · EDGAR ↗
Q1 2022$563M106May 10, 202213F-HRchanges · EDGAR ↗
Q4 2021$664M108Feb 11, 202213F-HRchanges · EDGAR ↗
Q3 2021$1.2B127Nov 15, 202113F-HRchanges · EDGAR ↗
Q2 2021$1.2B127Aug 16, 202113F-HRchanges · EDGAR ↗
Q1 2021$1.3B113May 14, 202113F-HRchanges · EDGAR ↗
Q4 2020$1.4B97Feb 12, 202113F-HRchanges · EDGAR ↗
Q3 2020$1.2B88Nov 13, 202013F-HRchanges · EDGAR ↗
Q2 2020$1.1B191Aug 13, 202013F-HRchanges · EDGAR ↗
Q1 2020$521M65May 13, 202013F-HRchanges · EDGAR ↗
Q4 2019$670M65Feb 12, 202013F-HRchanges · EDGAR ↗
Q3 2019$580M63Nov 14, 201913F-HRchanges · EDGAR ↗
Q2 2019$836M92Aug 14, 201913F-HRchanges · EDGAR ↗
Q1 2019$831M106May 14, 201913F-HRchanges · EDGAR ↗
Q4 2018$736M104Feb 12, 201913F-HRchanges · EDGAR ↗

13F filings are due up to 45 days after quarter end, so holdings shown here lag the fund’s current book. Source: original SEC filing on EDGAR ↗.