SEC 13F Intelligence

SEPNSEPTERNA INC

CUSIP 81734D104 · Yahoo Finance ↗ · Google Finance ↗

Septerna Inc (SEPN) has 5 institutional holders in Filings Flow’s 13F database, together reporting 45.91M shares worth $1.1B as of Q1 2026. The largest reported holders are Ra Capital Management, L.P., Trv GP V, LLC, and Driehaus Capital Management LLC.

Institutional Holders
5
Q1 2026
Reported Value
$561,874
Ticker
SEPN
Quarters Tracked
3

Ownership Trend

Institutional holders
Q4 ’25: 122Q4 ’25Q1 ’26: 124Q1 ’26Q2 ’26: 5Q2 ’26filingsflow.com
Total reported value
Q4 ’25: $1.3BQ4 ’25Q1 ’26: $1.1BQ1 ’26Q2 ’26: $561,874Q2 ’26filingsflow.com

Holders

Mixed quarters
Manager% of PortfolioValueSharesQuarter
TRV GP VI, LLC$136M AUM74.64%$101M4.21MQ1 2026OLDER
TRV GP V, LLC$401M AUM37.25%$149M6.22MQ1 2026OLDER
Samsara BioCapital, LLC$1.0B AUM7.35%$76M3.15MQ1 2026OLDER
Kalehua Capital Management LLC$260M AUM6.61%$9M389.1KQ1 2026OLDER
RA CAPITAL MANAGEMENT, L.P.$9.4B AUM1.78%$168M7.00MQ1 2026OLDER
First Light Asset Management, LLC$1.1B AUM1.58%$18M732.9KQ1 2026OLDER
ADAR1 Capital Management, LLC$1.7B AUM1.54%$26M1.09MQ1 2026OLDER
Catalio Capital Management, LP$479M AUM1.48%$7M294.4KQ1 2026OLDER
Siren, L.L.C.$3.6B AUM1.33%$48M2.00MQ1 2026OLDER
BVF INC/IL$3.1B AUM1.04%$33M1.35MQ1 2026OLDER
Casdin Capital, LLC$1.3B AUM1.01%$13M553.3KQ1 2026OLDER
Rangeley Capital, LLC$103M AUM0.93%$956,39439.8KQ1 2026OLDER
Sio Capital Management, LLC$697M AUM0.90%$4M189.2KQ3 2025OLDER
Checkpoint Capital L.P.$279M AUM0.86%$2M100.3KQ1 2026OLDER
DRIEHAUS CAPITAL MANAGEMENT LLC$13.6B AUM0.78%$106M4.40MQ1 2026OLDER
HighVista Strategies LLC$362M AUM0.56%$2M78.7KQ4 2025OLDER
HUSSMAN STRATEGIC ADVISORS, INC.$463M AUM0.55%$3M105.0KQ1 2026OLDER
Venrock Adviser, LLC$2.7B AUM0.45%$12M506.1KQ1 2026OLDER
Avoro Capital Advisors LLC$10.2B AUM0.32%$32M1.34MQ1 2026OLDER
Soleus Capital Management, L.P.$2.5B AUM0.27%$7M275.0KQ1 2026OLDER
PERCEPTIVE ADVISORS LLC$5.1B AUM0.22%$12M433.2KQ4 2025OLDER
VARCOV Co.$268M AUM0.15%$402,55116.8KQ1 2026OLDER
EntryPoint Capital, LLC$341M AUM0.09%$307,00712.8KQ1 2026OLDER
Seven Fleet Capital Management LP$318M AUM0.09%$275,02311.4KQ2 2026
Virtus Investment Advisers, LLC$363M AUM0.07%$257,57810.7KQ1 2026OLDER
Dynamic Technology Lab Private Ltd$615M AUM0.07%$301,00010.8KQ4 2025OLDER
Longaeva Partners L.P.$2.7B AUM0.07%$2M74.6KQ1 2026OLDER
Sofinnova Investments, Inc.$2.6B AUM0.04%$1M47.5KQ1 2026OLDER
Woodline Partners LP$26.4B AUM0.04%$11M385.3KQ4 2025OLDER
Numerai GP LLC$997M AUM0.04%$362,42015.1KQ1 2026OLDER
Logos Global Management LP$2.0B AUM0.03%$565,85823.5KQ1 2026OLDER
China Universal Asset Management Co., Ltd.$1.3B AUM0.02%$287,06211.9KQ1 2026OLDER
Atom Investors LP$1.4B AUM0.02%$272,9739.8KQ4 2025OLDER
PRIMECAP MANAGEMENT CO/CA/$127.0B AUM0.02%$25M1.05MQ1 2026OLDER
Baader Bank Aktiengesellschaft$1.3B AUM0.02%$278,80010.0KQ4 2025OLDER
Jump Financial, LLC$7.5B AUM0.02%$1M53.0KQ1 2026OLDER
XTX Topco Ltd$5.8B AUM0.02%$882,45436.7KQ1 2026OLDER
Y-Intercept (Hong Kong) Ltd$5.3B AUM0.01%$619,25325.8KQ1 2026OLDER
Janus Henderson Group Ltd.$209.4B AUM0.01%$21M890.8KQ1 2026OLDER
Universal- Beteiligungs- und Servicegesellschaft mbH$58.1B AUM0.01%$5M224.0KQ1 2026OLDER
ExodusPoint Capital Management, LP$12.6B AUM0.01%$1M37.9KQ4 2025OLDER
GOLDMAN SACHS GROUP INC$870.9B AUM0.01%$70M2.91MQ1 2026OLDER
WINTON GROUP Ltd$2.9B AUM0.01%$212,4738.8KQ1 2026OLDER
BALYASNY ASSET MANAGEMENT L.P.$77.1B AUM0.01%$6M236.7KQ1 2026OLDER
Trexquant Investment LP$13.9B AUM0.01%$848,28335.3KQ1 2026OLDER
Graham Capital Management, L.P.$4.1B AUM0.01%$250,1119.0KQ4 2025OLDER
Walleye Capital LLC$24.0B AUM0.01%$2M80.3KQ3 2025OLDER
Engineers Gate Manager LP$8.0B AUM0.00%$397,16816.5KQ1 2026OLDER
FEDERATED HERMES, INC.$61.5B AUM0.00%$2M89.3KQ1 2026OLDER
INTECH INVESTMENT MANAGEMENT LLC$10.2B AUM0.00%$370,33013.3KQ4 2025OLDER
Quarry LP$558M AUM0.00%$20,185724Q4 2025OLDER
JACOBS LEVY EQUITY MANAGEMENT, INC$23.8B AUM0.00%$683,31728.4KQ1 2026OLDER
Alyeska Investment Group, L.P.$35.4B AUM0.00%$841,05035.0KQ1 2026OLDER
Verition Fund Management LLC$15.4B AUM0.00%$296,60212.3KQ1 2026OLDER
MetLife Investment Management, LLC$19.6B AUM0.00%$328,85113.7KQ1 2026OLDER
STRS OHIO$25.2B AUM0.00%$413,31617.2KQ1 2026OLDER
TWO SIGMA INVESTMENTS, LP$123.9B AUM0.00%$2M75.4KQ1 2026OLDER
Ameritas Investment Partners, Inc.$3.3B AUM0.00%$46,7141.9KQ1 2026OLDER
RENAISSANCE TECHNOLOGIES LLC$63.9B AUM0.00%$905,93137.7KQ1 2026OLDER
GAMMA Investing LLC$2.7B AUM0.00%$37,4751.1KQ2 2026
LOS ANGELES CAPITAL MANAGEMENT LLC$25.4B AUM0.00%$341,56214.2KQ1 2026OLDER
MILLENNIUM MANAGEMENT LLC$240.3B AUM0.00%$3M124.1KQ1 2026OLDER
Cornerstone Financial Management LLC$109M AUM0.00%$1,25052Q1 2026OLDER
Police & Firemen's Retirement System of New Jersey$11.7B AUM0.00%$124,3555.2KQ1 2026OLDER
GEODE CAPITAL MANAGEMENT, LLC$1.61T AUM0.00%$16M645.1KQ1 2026OLDER
MARSHALL WACE, LLP$100.4B AUM0.00%$957,35439.8KQ1 2026OLDER
VANGUARD FIDUCIARY TRUST CO$396.1B AUM0.00%$4M154.5KQ1 2026OLDER
TUDOR INVESTMENT CORP ET AL$53.9B AUM0.00%$503,31818.1KQ4 2025OLDER
ADAGE CAPITAL PARTNERS GP, L.L.C.$64.8B AUM0.00%$576,72024.0KQ1 2026OLDER
DIADEMA PARTNERS LP$588M AUM0.00%$4,854202Q1 2026OLDER
Pinnacle Wealth Planning Services, Inc.$968M AUM0.00%$7,738322Q1 2026OLDER
Versant Capital Management, Inc$1.1B AUM0.00%$8,741261Q2 2026
BlackRock, Inc.$5.72T AUM0.00%$44M1.82MQ1 2026OLDER
AMERICAN CENTURY COMPANIES INC$194.3B AUM0.00%$1M61.3KQ1 2026OLDER
VANGUARD CAPITAL MANAGEMENT LLC$4.04T AUM0.00%$29M1.20MQ1 2026OLDER
CHARLES SCHWAB INVESTMENT MANAGEMENT INC$654.5B AUM0.00%$4M181.6KQ1 2026OLDER
Global Retirement Partners, LLC$5.6B AUM0.00%$35,0171.3KQ4 2025OLDER
VANGUARD GROUP INC$6.90T AUM0.00%$42M1.51MQ4 2025OLDER
RHUMBLINE ADVISERS$116.9B AUM0.00%$639,28526.6KQ1 2026OLDER
STATE STREET CORP$2.90T AUM0.00%$15M631.4KQ1 2026OLDER
JANE STREET GROUP, LLC$777.2B AUM0.00%$3M124.3KQ4 2025OLDER
NORTHERN TRUST CORP$756.6B AUM0.00%$4M164.5KQ1 2026OLDER
Man Group plc$55.1B AUM0.00%$284,94811.9KQ1 2026OLDER
Squarepoint Ops LLC$85.1B AUM0.00%$434,53418.1KQ1 2026OLDER
Tower Research Capital LLC (TRC)$3.8B AUM0.00%$17,230717Q1 2026OLDER
OSAIC HOLDINGS, INC.$68.3B AUM0.00%$305,13212.7KQ1 2026OLDER
UBS Group AG$666.3B AUM0.00%$3M117.0KQ1 2026OLDER
GF FUND MANAGEMENT CO. LTD.$6.0B AUM0.00%$24,1741.0KQ1 2026OLDER
CITADEL ADVISORS LLC$618.5B AUM0.00%$2M87.8KQ4 2025OLDER
SIGNATUREFD, LLC$6.5B AUM0.00%$23,213966Q1 2026OLDER
BANK OF NOVA SCOTIA$57.2B AUM0.00%$231,4048.3KQ4 2025OLDER
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.$73.7B AUM0.00%$240,80510.0KQ1 2026OLDER
Sterling Capital Management LLC$5.3B AUM0.00%$17,109712Q1 2026OLDER
N.E.W. Advisory Services LLC$1.3B AUM0.00%$4,325180Q1 2026OLDER
Swiss National Bank$173.8B AUM0.00%$531,06322.1KQ1 2026OLDER
Invesco Ltd.$653.3B AUM0.00%$2M82.9KQ1 2026OLDER
Russell Investments Group, Ltd.$93.1B AUM0.00%$276,70811.5KQ1 2026OLDER
Vanguard Investments Australia, Ltd.$34.6B AUM0.00%$93,5973.9KQ1 2026OLDER
PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO$30.9B AUM0.00%$81,0773.4KQ1 2026OLDER
Bank of New York Mellon Corp$543.9B AUM0.00%$1M58.7KQ1 2026OLDER
VANGUARD PORTFOLIO MANAGEMENT LLC$1.91T AUM0.00%$5M195.0KQ1 2026OLDER
Aster Capital Management (DIFC) Ltd$306M AUM0.00%$55820Q4 2025OLDER
KLP KAPITALFORVALTNING AS$25.5B AUM0.00%$60,0752.5KQ1 2026OLDER
Vanguard Global Advisers, LLC$186.5B AUM0.00%$390,41516.2KQ1 2026OLDER
SUSQUEHANNA INTERNATIONAL GROUP, LLP$893.3B AUM0.00%$2M73.0KQ1 2026OLDER
Nuveen, LLC$369.3B AUM0.00%$701,09929.2KQ1 2026OLDER
NEW YORK STATE COMMON RETIREMENT FUND$71.6B AUM0.00%$134,5685.6KQ1 2026OLDER
ALLIANCEBERNSTEIN L.P.$308.8B AUM0.00%$546,44819.6KQ1 2026OLDER
MORGAN STANLEY$1.67T AUM0.00%$3M104.0KQ1 2026OLDER
AQR CAPITAL MANAGEMENT LLC$218.4B AUM0.00%$369,46115.4KQ1 2026OLDER
Caitong International Asset Management Co., Ltd$541M AUM0.00%$91338Q1 2026OLDER
Larson Financial Group LLC$3.1B AUM0.00%$4,902204Q1 2026OLDER
VANGUARD ASSET MANAGEMENT, Ltd$117.0B AUM0.00%$178,3037.4KQ1 2026OLDER
DEUTSCHE BANK AG\$302.7B AUM0.00%$404,73716.8KQ1 2026OLDER
BARCLAYS PLC$416.3B AUM0.00%$545,81822.7KQ1 2026OLDER
JPMORGAN CHASE & CO$1.56T AUM0.00%$2M84.7KQ1 2026OLDER
FRANKLIN RESOURCES INC$408.3B AUM0.00%$469,83416.9KQ4 2025OLDER
Fortitude Family Office, LLC$448M AUM0.00%$48120Q1 2026OLDER
CITIGROUP INC$234.5B AUM0.00%$220,9569.2KQ1 2026OLDER
MassMutual Private Wealth & Trust, FSB$3.9B AUM0.00%$3,483104Q2 2026
AMERIPRISE FINANCIAL INC$431.8B AUM0.00%$392,82914.1KQ4 2025OLDER
MASSACHUSETTS FINANCIAL SERVICES CO /MA/$297.5B AUM0.00%$249,48010.4KQ1 2026OLDER
PRICE T ROWE ASSOCIATES INC /MD/$865M AUM0.00%$67528.1KQ1 2026OLDER
NISA INVESTMENT ADVISORS, LLC$27.0B AUM0.00%$20,209841Q1 2026OLDER
BNP PARIBAS FINANCIAL MARKETS$205.8B AUM0.00%$128,8255.4KQ1 2026OLDER
CWM, LLC$38.1B AUM0.00%$21,483894Q1 2026OLDER
EverSource Wealth Advisors, LLC$3.3B AUM0.00%$1,63468Q1 2026OLDER
GROUP ONE TRADING LLC$52.2B AUM0.00%$26,319944Q4 2025OLDER
BANK OF AMERICA CORP /DE/$1.37T AUM0.00%$624,13126.0KQ1 2026OLDER
WELLS FARGO & COMPANY/MN$530.3B AUM0.00%$237,1529.9KQ2 2026
ROTHSCHILD INVESTMENT LLC$1.9B AUM0.00%$72130Q1 2026OLDER
SBI Securities Co., Ltd.$3.6B AUM0.00%$1,32255Q1 2026OLDER
Legal & General Group Plc$432.4B AUM0.00%$137,8115.7KQ1 2026OLDER
FMR LLC$1.90T AUM0.00%$563,40723.4KQ1 2026OLDER
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM$94.5B AUM0.00%$27,8031.2KQ1 2026OLDER
Zurcher Kantonalbank (Zurich Cantonalbank)$46.0B AUM0.00%$12,207508Q1 2026OLDER
Mirae Asset Global Investments Co., Ltd.$299.3B AUM0.00%$56,1102.3KQ1 2026OLDER
Daiwa Securities Group Inc.$34.8B AUM0.00%$4149Q4 2025OLDER
US BANCORP \DE\$82.4B AUM0.00%$4,734197Q1 2026OLDER
QUADRANT CAPITAL GROUP LLC$3.3B AUM0.00%$1697Q1 2026OLDER
ROYAL BANK OF CANADA$570.1B AUM0.00%$18,000628Q4 2025OLDER
Arax Advisory Partners$3.5B AUM0.00%$843Q4 2025OLDER
Allworth Financial LP$24.7B AUM0.00%$40917Q1 2026OLDER
Farther Finance Advisors, LLC$10.6B AUM0.00%$1717Q1 2026OLDER
MAI Capital Management$17.7B AUM0.00%$1456Q1 2026OLDER
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC$481.0B AUM0.00%$3,725155Q1 2026OLDER
PNC FINANCIAL SERVICES GROUP, INC.$173.2B AUM0.00%$1,03343Q1 2026OLDER
NATIONAL BANK OF CANADA /FI/$111.5B AUM0.00%$1508Q3 2025OLDER

Holdings are reported up to 45 days after quarter end. Share counts are as filed and not adjusted for stock splits.