SEC 13F Intelligence

Managers / Q3 2025 · view latest →

Boxer Capital Management, LLC

CIK 0002018299 · 12860 EL CAMINO REAL, SUITE 300, SAN DIEGO, CA, 92130 · 8584003115

Reported Value
$314M
Q3 2025
Positions
34
Filings on Record
9
2019–present window
Filed
Nov 14, 2025
original filing

Summary

Boxer Capital Management, LLC reported $314M in U.S.-listed holdings across 34 positions for Q3 2025.

The portfolio is heavily concentrated: TNGX alone accounts for 26.2% of reported value.

Compared with Q2 2025, the fund opened 15 new positions and exited 1.

Portfolio Metrics

Turnover
+18.4%
vs prior filed quarter
Top-10 Concentration
+75.2%
share of reported value
Largest Position
+26.2%
Tango Therapeutics
New / Exited
15 / 1
positions this quarter

Methodology: turnover is min(value bought, value sold) ÷ average reported value across the two quarters — value-based, so market moves inflate it slightly versus a share-based measure. Concentration and largest position are shares of the filing’s total reported value, options excluded. New/exited counts compare against the prior filed quarter. All figures derive solely from the fund’s 13F filings.

Reported Value by Quarter

13F Reported Value
Q4 ’24: $1.2BQ4 ’24Q1 ’25: $332MQ1 ’25Q2 ’25: $199MQ2 ’25Q3 ’25: $314MQ3 ’25Q4 ’25: $457MQ4 ’25Q1 ’26: $762MQ1 ’26filingsflow.com

Portfolio Composition

By security type
Common Stock: 72.9%Other: 23.9%ADR: 3.2%Equity WRT: 0.0%
  • Common Stock · 72.9% · $229M
  • Other · 23.9% · $75M
  • ADR · 3.2% · $10M
  • Equity WRT · 0.0% · $54,893

Quarter-over-Quarter Changes full breakdown →

vs Q2 2025 (amended baseline)

IssuerMoveShare ΔShares nowValue ΔValue now
PTCTPTC THERAPEUTICS INCNEW+200.0K200.0K+$12M$12M
CYTKCYTOKINETICS INCNEW+200.0K200.0K+$11M$11M
ABVXABIVAX SANEW+120.0K120.0K+$10M$10M
INOINOVIO PHARMACEUTICALS INCNEW+2.30M2.30M+$5M$5M
CELCCELCUITY INCNEW+90.0K90.0K+$4M$4M
SLDBSOLID BIOSCIENCES INCNEW+600.0K600.0K+$4M$4M
DNLIDENALI THERAPEUTICS INCNEW+250.0K250.0K+$4M$4M
PGENPRECIGEN INCNEW+850.0K850.0K+$3M$3M

Value changes conflate price moves with buying and selling — share changes are the real signal. Share counts are not split-adjusted.

Holdings — Q3 2025

34 positions
#IssuerClass% PortfolioValueShares
1TNGXTANGO THERAPEUTICS INChistory →COM26.16%$82M9.77M
2UNIQURE NVSHS14.88%$47M800.0K
3RVMDREVOLUTION MEDICINES INChistory →COM5.95%$19M400.0K
4KYMRKYMERA THERAPEUTICS INChistory →COM5.76%$18M319.1K
5KODKODIAK SCIENCES INChistory →COM3.91%$12M750.0K
6PTCTPTC THERAPEUTICS INChistory →COM3.91%$12M200.0K
7AMLXAMYLYX PHARMACEUTICALS INChistory →COM3.90%$12M900.0K
8UROGEN PHARMA LTDCOM3.66%$11M575.0K
9MERUS N VCOM3.60%$11M120.0K
10CYTKCYTOKINETICS INChistory →COM NEW3.50%$11M200.0K
11ABVXABIVAX SAhistory →SPONSORED ADS3.25%$10M120.0K
12PTGXPROTAGONIST THERAPEUTICS INChistory →COM2.33%$7M110.0K
13NKTRNEKTAR THERAPEUTICShistory →COM NEW2.27%$7M125.0K
14CRESCENT BIOPHARMA INC.COM1.72%$5M453.7K
15INOINOVIO PHARMACEUTICALS INChistory →COM SHS1.72%$5M2.30M
16SRPTSAREPTA THERAPEUTICS INChistory →COM1.54%$5M250.0K
17CDTXCIDARA THERAPEUTICS INChistory →COM NEW1.47%$5M48.0K
18CELCCELCUITY INChistory →COM1.42%$4M90.0K
19REPLREPLIMUNE GROUP INChistory →COM1.40%$4M1.05M
20SLDBSOLID BIOSCIENCES INChistory →COM NEW1.18%$4M600.0K
21DNLIDENALI THERAPEUTICS INChistory →COM1.16%$4M250.0K
22PGENPRECIGEN INCCOM0.89%$3M850.0K
23APGEAPOGEE THERAPEUTICS INCCOM0.63%$2M50.0K
24BRD1EURMIND MEDICINE MINDMED INCCOM NEW0.61%$2M163.5K
25MLTXMOONLAKE IMMUNOTHERAPEUTICSCLASS A ORD0.57%$2M250.0K
26NRIXNURIX THERAPEUTICS INCCOM0.52%$2M175.0K
27AVTXAVALO THERAPEUTICS INCCOM NEW0.51%$2M125.0K
28MISTMILESTONE PHARMACEUTICALS INCOM0.42%$1M666.7K
29PEPGPEPGEN INCCOM0.37%$1M250.0K
30LBRXLB PHARMACEUTICALS INCCOM SHS0.35%$1M70.0K
31TILINSTIL BIO INCCOM NEW0.35%$1M60.7K
324XC1KALVISTA PHARMACEUTICALS INCCOM0.08%$248,47220.4K
33NUVB/WSNUVATION BIO INC*W EXP 02/10/2020.02%$53,893266.7K
34SRZNWSURROZEN INC*W EXP 08/01/2030.00%$1,00066.7K

Filing History

QuarterReported ValuePositionsFiledTypeLinks
Q1 2026$762M54May 15, 202613F-HRchanges · EDGAR ↗
Q4 2025$457M45Feb 17, 202613F-HRchanges · EDGAR ↗
Q3 2025$314M34Nov 14, 202513F-HRchanges · EDGAR ↗
Q2 2025$199M20Aug 14, 202513F-HRchanges · EDGAR ↗
Q1 2025$332M28May 15, 202513F-HRchanges · EDGAR ↗
Q4 2024$1.2B60Feb 14, 202513F-HRchanges · EDGAR ↗

13F filings are due up to 45 days after quarter end, so holdings shown here lag the fund’s current book. Source: original SEC filing on EDGAR ↗.