SEC 13F Intelligence

Managers / Q1 2026

Ishara Investments LP

CIK 0002111609 · 8929 EXPOSITION BLVD., LOS ANGELES, CA, 90034 · (818) 983-4448

Reported Value
$106M
Q1 2026
Positions
37
Filings on Record
2
2019–present window
Filed
May 15, 2026
original filing

Summary

Ishara Investments LP reported $106M in U.S.-listed holdings across 37 positions for Q1 2026.

Its largest position, PRAX, represents 6.9% of the portfolio.

Compared with Q4 2025, the fund opened 17 new positions and exited 19.

Portfolio Metrics

Turnover
+39.7%
vs prior filed quarter
Top-10 Concentration
+47.8%
share of reported value
Largest Position
+6.9%
Praxis Precision Medicines I
New / Exited
17 / 19
positions this quarter

Methodology: turnover is min(value bought, value sold) ÷ average reported value across the two quarters — value-based, so market moves inflate it slightly versus a share-based measure. Concentration and largest position are shares of the filing’s total reported value, options excluded. New/exited counts compare against the prior filed quarter. All figures derive solely from the fund’s 13F filings.

Reported Value by Quarter

13F Reported Value
Q4 ’25: $87MQ4 ’25Q1 ’26: $106MQ1 ’26filingsflow.com

Portfolio Composition

By security type
Common Stock: 92.6%ADR: 4.8%Other: 2.6%
  • Common Stock · 92.6% · $98M
  • ADR · 4.8% · $5M
  • Other · 2.6% · $3M

Quarter-over-Quarter Changes full breakdown →

vs Q4 2025 (amended baseline)

IssuerMoveShare ΔShares nowValue ΔValue now
AXSMAXSOME THERAPEUTICS INC.NEW+41.0K41.0K+$7M$7M
4XC1KALVISTA PHARMACEUTICALS INCNEW+276.8K276.8K+$6M$6M
ARWRARROWHEAD PHARMACEUTICALS INNEW+55.4K55.4K+$3M$3M
VERAVERA THERAPEUTICS INCNEW+82.0K82.0K+$3M$3M
TVTXTRAVERE THERAPEUTICS INCNEW+110.7K110.7K+$3M$3M
MLTXMOONLAKE IMMUNOTHERAPEUTICSNEW+174.3K174.3K+$3M$3M
SRRKSCHOLAR ROCK HLDG CORPNEW+57.4K57.4K+$3M$3M
ARDXARDELYX INCNEW+451.0K451.0K+$3M$3M

Value changes conflate price moves with buying and selling — share changes are the real signal. Share counts are not split-adjusted.

Holdings — Q1 2026

36 positions
#IssuerClass% PortfolioValueShares
1PRAXPRAXIS PRECISION MEDICINES Ihistory →COM NEW6.88%$7M22.6K
2AXSMAXSOME THERAPEUTICS INC.history →COM6.56%$7M41.0K
3XERSXERIS BIOPHARMA HOLDINGS INChistory →COM5.63%$6M1.02M
44XC1KALVISTA PHARMACEUTICALS INChistory →COM5.27%$6M276.8K
5AM6AMICUS THERAPEUTIChistory →COM5.05%$5M369.0K
6BMRNBIOMARIN PHARMACEUTICAL INChistory →COM4.39%$5M82.0K
7VSTMVERASTEM INChistory →COM NEW4.11%$4M820.0K
8RAREULTRAGENYX PHARMACEUTICAL INhistory →COM3.46%$4M174.3K
9ARWRARROWHEAD PHARMACEUTICALS INhistory →COM3.29%$3M55.4K
10PCVXVAXCYTE INChistory →COM3.16%$3M57.4K
11VERAVERA THERAPEUTICS INChistory →CL A3.12%$3M82.0K
12TVTXTRAVERE THERAPEUTICS INChistory →COM3.11%$3M110.7K
13MLTXMOONLAKE IMMUNOTHERAPEUTICShistory →CLASS A ORD3.08%$3M174.3K
14ZNTLZENTALIS PHARMACEUTICALS INChistory →COM2.72%$3M1.23M
15SRRKSCHOLAR ROCK HLDG CORPhistory →COM2.67%$3M57.4K
16ACADACADIA PHARMACEUTICALS INChistory →COM2.59%$3M123.0K
17ARDXARDELYX INChistory →COM2.56%$3M451.0K
18MLYSMINERALYS THERAPEUTICS INChistory →COM2.10%$2M82.0K
19GMABGENMAB A/Shistory →SPONSORED ADS2.08%$2M82.0K
20DBVTDBV TECHNOLOGIES S Ahistory →SPONSORED ADS2.03%$2M102.5K
21CN2CATALYST PHARMACEUTICALS INChistory →COM1.92%$2M82.0K
22SIONSIONNA THERAPEUTICS INChistory →COM1.87%$2M49.2K
23CTNMCONTINEUM THERAPEUTICS INChistory →CL A1.76%$2M142.0K
24ALNYALNYLAM PHARMACEUTICALS INChistory →COM1.61%$2M5.1K
25LGNDLIGAND PHARMACEUTICALS INChistory →COM NEW1.55%$2M8.2K
26EWTXEDGEWISE THERAPEUTICS INChistory →COM1.47%$2M49.2K
27IMMATICS N.VSHS1.43%$2M153.8K
28LXRXLEXICON PHARMACEUTICALS INChistory →COM NEW1.33%$1M902.0K
29BEAMBEAM THERAPEUTICS INChistory →COM1.29%$1M57.4K
30ORICORIC PHARMACEUTICALS INChistory →COM1.23%$1M102.5K
31NEWAMSTERDAM PHARMA COMPANYORDINARY SHARES1.12%$1M36.9K
32ANNXANNEXON INCCOM0.91%$965,345174.3K
33IDYAIDEAYA BIOSCIENCES INCCOM0.78%$819,67224.6K
34SLNSILENCE THERAPEUTICS PLCADS0.70%$740,435140.5K
35PTCTPTC THERAPEUTICS INCCOM0.66%$698,33310.3K
36GOSSGOSSAMER BIO INCCOM0.26%$269,370820.0K

Filing History

QuarterReported ValuePositionsFiledTypeLinks
Q1 2026$106M37May 15, 202613F-HRchanges · EDGAR ↗
Q4 2025$87M38Feb 17, 202613F-HRchanges · EDGAR ↗

13F filings are due up to 45 days after quarter end, so holdings shown here lag the fund’s current book. Source: original SEC filing on EDGAR ↗.