SEC 13F Intelligence

Two Sigma Advisers, LP / ISI

Two Sigma Advisers, LP’s Ionis Pharmaceuticals Inc Position

Does Two Sigma Advisers, LP own Ionis Pharmaceuticals Inc (ISI)? Not currently — the last reported position was 3.05M shares worth $241M in Q4 2025; the fund’s latest 13F (Q1 2026) no longer reports it.

Position Value
$241M
Q4 2025
Shares
3.05M
% of Portfolio
+0.47%
Quarters Held
29
position exited

Position History ISI

Reported value by quarter
Q4 ’18: $33MQ4 ’18Q1 ’19: $65MQ2 ’19: $105MQ3 ’19: $97MQ4 ’19: $83MQ4 ’19Q1 ’20: $56MQ2 ’20: $69MQ3 ’20: $52MQ4 ’20: $45MQ4 ’20Q1 ’21: $32MQ2 ’21: $21MQ3 ’21: $14MQ4 ’21: $15MQ4 ’21Q1 ’22: $23MQ2 ’22: $26MQ3 ’22: $29MQ4 ’22: $24MQ4 ’22Q1 ’23: $12MQ2 ’23: $14MQ3 ’23: $27MQ4 ’23: $39MQ4 ’23Q1 ’24: $45MQ2 ’24: $61MQ3 ’24: $53MQ4 ’24: $47MQ4 ’24Q1 ’25: $63MQ2 ’25: $105MQ3 ’25: $136MQ4 ’25: $241MQ4 ’25filingsflow.com
QuarterSharesValue% of Portfolio
Q4 20253.05M$241M+0.47%
Q3 20252.07M$136M+0.27%
Q2 20252.67M$105M+0.22%
Q1 20252.09M$63M+0.14%
Q4 20241.35M$47M+0.11%
Q3 20241.33M$53M+0.13%
Q2 20241.29M$61M+0.14%
Q1 20241.04M$45M+0.10%
Q4 2023777.0K$39M+0.09%
Q3 2023604.3K$27M+0.07%
Q2 2023344.2K$14M+0.04%
Q1 2023345.8K$12M+0.03%
Q4 2022634.9K$24M+0.07%
Q3 2022657.5K$29M+0.08%
Q2 2022705.8K$26M+0.07%
Q1 2022611.6K$23M+0.06%
Q4 2021497.4K$15M+0.04%
Q3 2021432.2K$14M+0.04%
Q2 2021525.8K$21M+0.06%
Q1 2021714.4K$32M+0.09%
Q4 2020800.2K$45M+0.12%
Q3 20201.09M$52M+0.15%
Q2 20201.17M$69M+0.20%
Q1 20201.19M$56M+0.21%
Q4 20191.37M$83M+0.19%
Q3 20191.61M$97M+0.24%
Q2 20191.63M$105M+0.26%
Q1 2019806.9K$65M+0.17%
Q4 2018606.9K$33M+0.09%

Common-stock position only; options are excluded. Quarters where the fund filed no 13F or reported no position are absent. See Two Sigma Advisers, LP’s full portfolio or all institutional holders of ISI.