SEC 13F Intelligence

Two Sigma Advisers, LP / ALNY

Two Sigma Advisers, LP’s Alnylam Pharmaceuticals Inc Position

Does Two Sigma Advisers, LP own Alnylam Pharmaceuticals Inc (ALNY)? Not currently — the last reported position was 1.13M shares worth $450M in Q4 2025; the fund’s latest 13F (Q1 2026) no longer reports it.

Position Value
$450M
Q4 2025
Shares
1.13M
% of Portfolio
+0.88%
Quarters Held
21
position exited

Position History ALNY

Reported value by quarter
Q4 ’18: $9MQ4 ’18Q1 ’19: $7MQ2 ’20: $1MQ4 ’20: $481,000Q4 ’20Q1 ’21: $5MQ4 ’21: $644,000Q1 ’22: $8MQ1 ’22Q2 ’22: $2MQ3 ’22: $13MQ4 ’22: $29MQ4 ’22Q1 ’23: $31MQ2 ’23: $37MQ3 ’23: $6MQ3 ’23Q1 ’24: $28MQ2 ’24: $63MQ3 ’24: $28MQ3 ’24Q4 ’24: $19MQ1 ’25: $74MQ2 ’25: $87MQ2 ’25Q3 ’25: $407MQ4 ’25: $450Mfilingsflow.com
QuarterSharesValue% of Portfolio
Q4 20251.13M$450M+0.88%
Q3 2025892.5K$407M+0.81%
Q2 2025266.1K$87M+0.18%
Q1 2025275.8K$74M+0.17%
Q4 202478.8K$19M+0.04%
Q3 2024103.1K$28M+0.07%
Q2 2024258.7K$63M+0.14%
Q1 2024189.6K$28M+0.07%
Q3 202335.9K$6M+0.02%
Q2 2023193.6K$37M+0.09%
Q1 2023155.1K$31M+0.08%
Q4 2022120.0K$29M+0.08%
Q3 202263.8K$13M+0.04%
Q2 202212.4K$2M+0.01%
Q1 202246.7K$8M+0.02%
Q4 20213.8K$644,0000.00%
Q1 202131.9K$5M+0.01%
Q4 20203.7K$481,0000.00%
Q2 20208.3K$1M0.00%
Q1 201970.8K$7M+0.02%
Q4 2018117.1K$9M+0.02%

Common-stock position only; options are excluded. Quarters where the fund filed no 13F or reported no position are absent. See Two Sigma Advisers, LP’s full portfolio or all institutional holders of ALNY.