SEC 13F Intelligence

Orbimed Advisors LLC / UPB

Orbimed Advisors LLC’s Upstream Bio Inc Position

Does Orbimed Advisors LLC own Upstream Bio Inc (UPB)? Yes — 5.69M shares worth $51M (+1.02% of its 13F portfolio) as of Q1 2026.

Position Value
$51M
Q1 2026
Shares
5.69M
% of Portfolio
+1.02%
Quarters Held
6
currently held

Position History UPB

Reported value by quarter
Q4 ’24: $94MQ4 ’24Q1 ’25: $35MQ1 ’25Q2 ’25: $63MQ2 ’25Q3 ’25: $107MQ3 ’25Q4 ’25: $155MQ4 ’25Q1 ’26: $51MQ1 ’26filingsflow.com
QuarterSharesValue% of Portfolio
Q1 20265.69M$51M+1.02%
Q4 20255.69M$155M+3.16%
Q3 20255.69M$107M+2.52%
Q2 20255.69M$63M+1.56%
Q1 20255.69M$35M+0.83%
Q4 20245.69M$94M+1.93%

Common-stock position only; options are excluded. Quarters where the fund filed no 13F or reported no position are absent. See Orbimed Advisors LLC’s full portfolio or all institutional holders of UPB.